Actinobacillus (Haemophilus) pleuropneumoniae

- morphology resembles Pasteurella

- hemorrhagic necrotizing pneumonia, fibrinous pleuritis in pigs

- high morbidity; lethality depends on environmental factors

- no healthy carriers

- survivors end up with chronic pneumonia

- transmission: aerosol

VIRULENCE FACTORS OTHER THAN LPS AND CAPSULE

- cytotoxins

- porcine transferin binding protein (lends host specificity)

therapy: penicillin

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Mannheimia (Pasteurella) haemolytica

- respiratory tract infections

• Shipping fever in cattle
• pneumonia, sepsis in lambs
• pneumonia, salpingitis, sepsis in fowl

- mastitis in ewes

- in addition to LPS, capsule, fimbriae, has:

• leukotoxin specific for ruminant leukocytes and platelets
  
• membrane protein that binds ruminant transferrin/ iron

- therapy: susceptibility testing to choose appropriate antibiotics

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Pasteurella

- facultative anerobe
- commensal on mucosa
- opportunist
- hemorrhagic sepsis in cattle
- fowl cholera
- respiratory tract infections (rabbits, cats, calves, pigs)

• rhinitis
• conjunctivitis
• otitis
• bronchitis
• pneumonia

- abscesses in humans, dogs and cats by bites and scratches

• associated with lymphadenitis, sepsis

- therapy: most antimicrobial agents

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