Saturday, October 25, 2008

Abnormal gonads: hermaphrodites

- types: bilateral, unilateral, lateral.
- hypospadia: incomplete masculinization of the penis.
- confirm your diagnosis via karyotype, histopathology
- chimera: mosaic, XX (may have SRY), or unknown
- possible causes:
  • congenital adrenal gland hyperplasia
  • fetal exposure to sex hormones
  • testicular feminization syndrome
  • XY gonadal dysgenesis
  • XY gonadal agenesis
  • chromosomal abnormalities

- interruption of DAX-1 expression may lead to hypogonadotropic hypogonadism

- SOX 9 regulates SRY expression

0 comments:

Post a Comment