Histophilus somni

- cattle = asymptomatic reservoir

DISEASES

- infections of the respiratory tract (thromboembolic meningoencephalitis)

- endometritis and abortion in cows

VIRULENCE FACTORS IN ADDITION TO LOS

- surface protein that binds bovine transferrin/iron

- Fc receptors have antiphagocytic effect

- resist neutrophils

- can survive w/in macrophages

REQUIRES

- thiamin (vitamin D1) pyrophosphate

- also likes CO2 (capnophilic)

therapy: penicillin